Purdue-Backed Startup Launches Innovative Crystallization Solutions for Pharma Industry
WEST LAFAYETTE, Ind. — Crystallization Systems Technology Inc. (CrySyst), a high-tech startup founded by Purdue University researchers, has launched to revolutionize crystallization processes in the pharmaceutical and fine chemical industries. The company’s quality-by-control (QbC) framework addresses significant challenges in crystallization monitoring, modeling, and control.
Zoltán Nagy, the Arvind Varma Professor of Chemical Engineering in Purdue University’s Davidson School of Chemical Engineering, and Botond Szilágyi, formerly a postdoctoral research associate at Purdue and now an associate professor at Budapest University of Technology and Economics, co-founded CrySyst. The Purdue Innovates Office of Technology Commercialization has issued a license for CrySyst to commercialize copyright technologies CryMoCo and CrySiV.
CrySyst’s software solutions directly address pain points in model-based process development by providing guided experiment selection, a semiautomated framework for model development, and reliable, high-confidence solutions. The company’s tools reduce time, material usage, and risk while enhancing process robustness and scalability.
Innovative Software Solutions
CryMoCo is an instrument vendor-independent crystallization process monitoring and control software that implements industry-standard communication protocols with typical process analytical technology tools and state-of-the-art process control methods. CrySiV is a user-friendly, interactive population balance model-based crystallization simulator for digital design of crystallization processes, including kinetic parameter regression, process simulation, and visualization.
Addressing Industry Challenges
Pharmaceutical and fine chemical companies face significant process development challenges due to limited material availability, constraints on experimental resources, and extensive timelines required for optimization through experiments alone. CrySyst’s solutions address these challenges through model-based digital design and model-free direct design approaches.
“We’re committed to helping our clients develop and scale their process technologies faster, using less material,” Nagy said. “We offer specialized software products for model-free and model-based crystallization process design as well as consultancy and training services for problem-solving with our software tools.”
The development of CrySyst’s tools was supported by funding from the Enabling Technologies Consortium, which included more than 10 of the largest pharmaceutical companies. The collaboration allowed the researchers to develop tools based on industry feedback, fitting the needs of the pharmaceutical sector.
About CrySyst
Crystallization Systems Technology is committed to helping pharmaceutical and fine chemical industries develop and scale-up their process technologies faster, using less material by applying cutting-edge crystallization monitoring, modeling, and control solutions.
About Purdue Innovates Office of Technology Commercialization
The Purdue Innovates Office of Technology Commercialization operates one of the most comprehensive technology transfer programs among leading research universities in the U.S., supporting economic development initiatives and commercializing Purdue intellectual property.
